Prakash Kinthada
JNTU University, India
Title: Transition Metal Complexes/Organomettalic Compounds As Anticancer/Anti HIV Drugs Or In Pharmaceutical Industry
Biography
Biography: Prakash Kinthada
Abstract
My talk would mainly encompass different transition metal complexes/organometallic compounds that are presently used as drugs, especially anticancer and anti-HIV drugs, apart from anti-inflammatory, antimicrobial, antibacterial and diseases like arthritis and Parkinson’s disease, etc. The talk would mainly focus on the use of medicinal chemistry and its application to drug design and development in pharmaceutical industry, especially transition metal complexes and organometallic compounds viz. gold, platinum, palladium and ruthenium apart from copper, cobalt, iron, nickel, zinc, cadmium, etc. We have synthesized and characterized several phytochemicals from traditional medicinal plants and isolated some phytochemicals and made the corresponding oximes, thiosemicarbazones and substituted thiosemicarbazones as ligands and synthesized, characterized, structurally elucidated their transition metal complexes especially with gold, platinum, palladium, ruthenium, copper, etc. and studied their anticancer activity, nuclease activity, etc. and tested their potential as anticancer drugs. The main aim of our extensive/preclinical pharmaceutical development program is to investigate the use of these extremely novel small molecules-metal complexes/compounds of phytochemicals, flavonoids, etc. The main aim of our research is design, development and synthesis of transition metal complexes/ organometallic compounds that would certainly help to bring this force of nature from bench to bedside and enhance cancer killing with less toxic effects and would certainly lead to initiation of clinical trials.