World Haematology and Medical Oncology Conference

Biography

Dr. Yi Zhang received his MD from Henan Medical University and MS from Tongji Medical University. He obtained his PhD at Université Catholique de Louvain in Belgium and did his postdoctoral training in Drs Thierry Boon and Pierre van der Bruggen’s lab in Ludwig Institute for Cancer Research, Brussels Branch. After that, he moved to University of Chicago and worked as Research Assistant Professor in Dr. Hans Schreiber’s lab. In 2005, he was recruited as Tenure-track Assistant Professor in Medical University of South Carolina. Currently, he is a distinguished Professor and Director in Biotherapy Center & Cancer Center at the First Affiliated Hospital of Zhengzhou University. His laboratory investigates the key cellular components such as effector T cells, regulatory immune cells and caner stem cells in tumor microenvironment and their clinical relevance, especially in lung cancer and esophageal cancer. He concentrates on the aberrant expression of cancer-testis (CT) antigens (such as MAGE-A3, MAGE-C2, NY-ESO-1 etc.) and the corresponding antigen-specific T cells in lung cancer and esophageal cancer. Furthermore, they are dedicated to develop TCR or CAR gene-modified T cells and against tumor antigens for potential antigen-specific T cell therapy. He published 184 papers and 85 publications in internationally peer-reviewed journals.

Research Interest

He concentrates on the aberrant expression of cancer-testis (CT) antigens (such as MAGE-A3, MAGE-C2, NY-ESO-1 etc.) and the corresponding antigen-specific T cells in lung cancer and esophageal cancer.