Shiow-Kang Yen
National Chung Hsing University,Taiwan
Title: Cathodic polarization test coupled with quartz crystal microbalance to investigate the deposition mechanism of Cisplatin on titanium
Biography
Biography: Shiow-Kang Yen
Abstract
To reduce the side effects of chemotherapy, target therapies have been spotlighted. In this study, Cisplatin, the drug for cancer treatment, is electrochemically deposited on titanium alloy as vascular stents for the tumor localized therapy by sustaining drug releasing to achieve the cancer cells apoptosis or the prevention of cancer metastasis. Coupled with quartz crystal microbalance, the cathodic polarization tests were conducted to speculate the deposition mechanism of Cisplatin on titanium, the field emission scanning electron microscope and Fourier transform infrared spectroscopy to observe the surface morphology and analyze constituent elements, respectively. A UV visible spectrometer was used to measure drug loading and releasing. It is concluded that the Cisplatin can be successfully deposited on titanium with drug 62.99 μg/cm2, by exchanging Cl- ions which is originally bonded on Cisplatin with OH- ions, is produced by the electrochemical method, finally to form strong hydrogen bonds and attract one another.